Article: Insulin facilitates repetitive spike firing in rat insular cortex via phosphoinositide 3-kinase but not mitogen activated protein kinase cascade.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Takei H; Fujita S; Shirakawa T; Koshikawa N; Kobayashi M Neuroscience, 2010
Table 2Effects of blockers of kinases on intrinsic electrophysiological properties of layerII/III pyramidal cells
†Resting membrane potential.⁎P<0.05,⁎⁎P<0.01,⁎⁎⁎P<0.001(Student's t-test).
Control | Lavendustin A | Wortmannin | Deguelin | PD 98059 | ||||||
Mean±SEM | n | Mean±SEM | n | Mean±SEM | n | Mean±SEM | n | Mean±SEM | n | |
Vm† (mV) | −73.5±2.2 | 20 | −79.8±3.2 | 6 | −74.8±1.5 | 23 | −78.1±2.5 | 8 | −78.0±2.3 | 15 |
Input resistance (MΩ) | 28.3±1.7 | 20 | 14.7±2.5⁎⁎⁎ | 6 | 28.2±1.6 | 18 | 20.1±2.1⁎ | 6 | 26.8±2.1 | 15 |
Rheobase (nA) | 0.55±0.06 | 19 | 0.78±0.06 | 6 | 0.67±0.05 | 16 | 0.79±0.13 | 6 | 0.71±0.06 | 13 |
f/I slope (Hz/nA) | 23.7±2.3 | 19 | 15.4±2.1 | 6 | 18.6±2.7 | 16 | 9.2±1.2⁎⁎ | 6 | 20.8±3.9 | 13 |
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Neocortex pyramidal cell layer 2-3 | Insular cortex layer 2-3 pyramidal cells | resting membrane potential (mV) | -73.5 ± 2.2 | -73.5 (mV) | Data Table |
Neocortex pyramidal cell layer 2-3 | Insular cortex layer 2-3 pyramidal cells | input resistance (MΩ) | 28.3 ± 1.7 | 28.3 (MΩ) | Data Table |
Neocortex pyramidal cell layer 2-3 | Insular cortex layer 2-3 pyramidal cells | rheobase (nA) | 0.55 ± 0.06 | 550.0 (pA) | Data Table |
Neocortex pyramidal cell layer 2-3 | Insular cortex layer 2-3 pyramidal cells | FI slope (Hz/nA) | 23.7 ± 2.3 | 23.7 (Hz/nA) | Data Table |